ABSTRACT
El uso de anticonceptivos orales sin importar la generación no se ha correlacionado claramente como único factor para la producción de enfermedades del sistema circulatorio; cuando hay efectos adversos se encuentra relacionado con mayor edad, antecedente cardiovascular, diabetes mellitus, y cigarrillo.Al realizar la investigación no se encontró relación, con el uso prolongado de anticonceptivos orales y enfermedad coronaria, aunque se recomienda efectuarotros estudios
Subject(s)
Contraceptives, Oral , Contraceptives, Oral, Combined , Contraceptives, Oral, Hormonal , Contraceptives, Oral, Sequential , Coronary DiseaseSubject(s)
Humans , Female , Adolescent , Adult , Middle Aged , Contraception/methods , Contraceptives, Oral, Combined , Contraceptives, Oral, Hormonal , Contraceptives, Oral, Sequential , Contraceptives, Postcoital , Abortion, Habitual , Breast Neoplasms , Cardiovascular Diseases , Climacteric , Diabetes Mellitus , Endometrial Neoplasms , Fertility , Hypertension , Ovarian Neoplasms , Risk Factors , Uterine Cervical NeoplasmsABSTRACT
Platelet aggregation time was significantly (P less than 0.01) decreased in female rabbits treated with oral contraceptive (a preparation containing low dose of estrogen) as also by injection of diethylstilbestrol (10 mg/kg), while in animals that received indomethacin (10 mg/kg) or aspirin (30 mg/kg) (PG synthetase inhibitors) along with oral contraceptives or diethylstilbestrol there was no significant alteration in platelet aggregation time. The increased synthesis of prostaglandins or some of the intermediary product like TXA2 might be responsible for this effect.